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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Percivalle S. 1, Caccialanza M. 1, Piccinno R. 1, Rozza M. 2
1 Department of Photoradiotherapy Institute of Dermatological Sciences Ospedale Maggiore, IRCCS, University of Milan, Milan, Italy
2 Department of Health Physics Ospedale Maggiore, IRCCS, University of Milan, Milan, Italy
Aim. In this study we have considered the efficacy and safety of phototherapy and photochemotherapy in patients suffering from polymorphous light eruption (PLE), when the other treatments had failed to offer satisfactory results.
Methods. Eighteen patients with PLE were enrolled in this retrospective study. Phototesting had been performed in 16 patients (determination of minimal erythema dose and provocation testing). The patients received ultraviolet irradiation on skin sites usually exposed, in spring time. During the course of treatment nobody applied topicals, except for emollient products, and there was no oral administration of substances that could modify the response to the therapy. Eleven patients received UVA radiations, 4 received UVA+UVB, 3 received PUVA. The patients attended phototherapy or photochemotherapy courses twice weekly; the median number of treatments was 19 for patients who received UVA (mean cumulative dose = 73.89 J/cm2), 24 for patients who received UVA+UVB (mean cumulative dose = 7.15 J/cm2), 33 for patients who received PUVA (mean cumulative dose = 63.03 J/cm2).
Results. The treatment was well tolerated. Patients were followed up in autumn, after summer sunlight exposure: 6 patients (33%) reported excellent results, 3 (17%) good results, 5 (28%) improved and 4 (22%) failed to improve.
Conclusion. This study confirms that desensitization phototherapy and photochemotherapy represent an effective therapeutic option in patients with severe PLE.
language: English, Italian