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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2004 February;139(1):31-46
language: English, Italian
Drug-induced non-histaminergic angioedema
Zampino M. R., Corazza M., Virgili A.
Section of Dermatology Department of Clinical and Experimental Medicine University of Ferrara, Ferrara, Italy
Angioedema (AE) is caused by various stimulating agents that lead to the release of chemical mediators capable of increasing vascular permeability at cutaneous and/or mucosal level. The pathogenetic mechanisms involved, whether of an immunological or non-immunological nature, lead to a wide range of clinical features in which histamine and the histamine-releasing cells can be considered the principal protagonists. The pathogenesis of non-immunological AE includes a C1-inhibitor deficiency and pharmacological mechanisms. This definition suggests that the causal agent probably acts with a biochemical mechanism rather than a histaminergic one. The purpose of this review is to offer a general survey of drug-associated AE, induced by mechanisms of a pharmacological-biochemical nature without activation of the immune system or release of histamine.