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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2003 December;138(6):513-7
Topical treatment of chronic pressure ulcers with Ustiosan
Ricci E. 1, Bosio D. 2, Nano M. 3
1 Centro Vulnologico Italiano, Torino,
2 Centro ricerche Biologiche La Carignana, Caselle Torinese,
3 Dipartimento di Fisiopatologia Clinica, Università degli Studi di Torino, Torino
Aim. Chronic pressure ulcers constitute a growing healthcare problem as the number of older persons increases. In Italy an estimated 3-4% of the population will eventually develop a chronic skin lesion. An important part of local treatment to promote skin repair is pain control and elimination of necrotic and infected tissue. This study evaluated the clinical performance of a topical preparation containing lidocaine, procaine and 8-oxyquinoline (Ustiosan®, Kelemata SpA, Turin) in the treatment and management of chronic pressure ulcers.
Methods. This open study used Ustiosan, a topical ointment containing procaine chlorhydrate (0.5%), lidocaine hydrate (0.5%) and 8-oxyquinoline sulphate for the treatment of chronic
pressure ulcers. The study group consisted of 20 outpatients (10 men, 10 women; mean age, 68.7 years; range, 19-91) with normal nutritional status; 18 presented with pressure ulcers, 1 with lower limb venous ulcer and 1 with Martorell’s ulcer of the lower limb.
Results. Healing was achieved in 20% of cases, an extremely promising finding even for such a short observation period. Wound margin recovery was attained in 90% of cases, and pain control was efficacious in 90%.
Conclusion. The results of this study suggest that Ustiosan may be advantageously used as Primary local treatment of uncomplicated chronic skin ulcers, particularly in painful lesions.