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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2003 December;138(6):507-11
Keratolytic action of an emollient cosmetic cream
Cervadoro G. 1, Cervadoro E. 2, Semeraro R. M. 2
1 Scuola di specializzazione in Dermatologia e Venerologia Università degli Studi di Pisa, Pisa
2 Clinica Dermatologica, Pisa
Aim. The aim of this study was to evaluate the efficacy of a new emollient cream with keratolytic action (urea at 40%) for the treatment of localized hyperkeratosis and palmoplantar keratoderma.
Methods. Two groups of patients, (including 12 patients each aged 26-72 years, suffering from localized hyperkeratosis and palmoplantar keratosis, and a control group with no skin lesions have been studied. The patients were followed-up for 4 weeks and hydration was evaluated by corneometer (Corneometer CM825).
Results. After 4 weeks, an improvement of hydration values was observed in patients with localized hyperkeratosis and palmoplantar keratosis (attinic keratosis, plantar and nail psoriasis).
Conclusion. The efficacy of this keratolytic cream with 40% urea has been confirmed in the treatment of palmoplantar keratosis, plantar and nails psoriasis and hyperkeratosis.