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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Lentini M., Batolo D.
Dipartimento di Patologia Umana-Anatomia Patologica Università degli Studi di Messina, Messina
Besides the classical forms, melanomas present a small percentage of uncommon histological variants. These can be grouped with different criteria. A schematic distinction is made according to the similarities with nevi, sarcomas and carcinomas. Another practical criterion can well distinguish identifìable uncommon melanomas from those presenting diagnostic problems (e.g. desmoplastic and myxoid mel- anomas) or those simulating nevi, and from melanomas be-longing to the blue nevi group. It is also possible to distinguish uncommon variants of melanomas according to the activity (amelanotic melanomas), the cytological features (spindle cell, small cell, plasmacytoid cell, signet-ring cell, balloon-cell melanomas), the cytological and structural features (nevoid, spitzoid melanomas), the stroma (desmoplastic, myxoid, osteocartilagineous melanomas), the biological behaviour and morphological features (minimal deviation melanomas), and the topographic and histological features (dermal, equine, combined, soft tissue melanomas, malignant blue nevi). Among these variants someone can present problems more than others in the differential diagnosis with melanocytic and mesenchymal neoplasia. For example, desmoplastic melanomas can show problems in the differential diagnosis with mesenchymal tumours in spite of the use of specific melanocytic and mesenchymal antigens.