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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2003 October;138(5):425-9
Efficacy and safety of a topically applied Avène spring water spray in the healing of facial skin after laser resurfacing
Sulimovic L. 1, Licu D. 2, Ledo E. 3, Naeyaert J. M. 4, Pigatto P. 5, Tzermias C. 6, Vasquez Doval J. 7, Dupuy P. 2
1 Private Practice, Paris, France
2 Institut de Recerche Pierre-Fabre, Vigoulet, France
3 Private Practice, Madrid, Spain
4 Universitair Ziekenhuis, Gent, Belgium
5 Istituto Dermatologico IRCCS, Ospedale Maggiore, Milano
6 Laser Dermatology Center, Athens, Greece
7 Private Practice, Pamplona, Spain
Aim. Laser resurfacing is a well-accepted treatment, but the onset of postlaser erythema associated with pain, itching, stinging and tightening may preclude patient’s acceptance of the procedure. The present study was conducted to evaluate a low-salt medical spring water (Avène, Avène-les-Bains, France), in conjunction with the standard use of an emollient, to improve tolerance by hydrating the postlaser skin.
Methods. A controlled, randomized, open-labeled, multicentric and 2 parallel group study was completed after 84 days in 74 patients, 34 applying a petrolatum ointment alone (control group), and 40 applying petrolatum ointment in association with the Avène spring water spray ad libitum (water group).
Results. The water spray showed a pronounced effect on reducing erythema, from the 2nd week of postlaser onwards, with a statistically significant difference in favor of the water group compared with the control group (p≤0.04 from day 14 to day 84, except a non-significant trend on day 28). In addition, the water spray was found to significantly reduce itching on day 28 (p<0.05), and stinging and tightening on day 14 and day 21 (p<0.05). Pain was not modified by the water.
Conclusion. Topical water appeared to be a helpful adjunctive treatment to petrolatum ointment for counteracting erythema, itching, stinging and tightening during the postlaser treatment period.