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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2002 June;137(3):189-92

language: Italian

Mal de Meleda. Description of a case

Solaroli C. 2, Albertazzi D. 1, Cervetti O. 1

1 Dipartimento di Discipline Medico-Chirurgiche Sezione Dermatologia II Università degli Studi di Torino, Torino
2 I Divisione Dermatologia Ospedaliera


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Mal de Meleda (Keratoderma palmoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma, characterized by hyperkeratosis of the palms and soles that appears as soon after birth and progressively (progrediens) involves other areas (transgrediens) of the body skin. The case reported is about a 31-year old woman, born from a consanguineous marriage, presenting since the age of 3 months fissured erythemato-squamous lesions on the palmar-plantar surfaces associated with severe hyperhidrosis. The 5th finger of the left hand had a circular hyperkeratotic ring, pseudo-ainhum-like. The peculiar clinical characteristics of the Mal de Meleda and the differential diagnosis are discussed. Pseudo-ainhum is an infrequent complication in the autosomal recessive keratoderma.

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