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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Hofmann U. B., Westphal J. R. *, Van Muijen G. N. P. *, Bröcker E.-B.
From the Department of Dermatology Julius-Maximilians University Würzburg, Germany
* Department of Pathology University Medical Center St. Radboud Nijmegen, The Netherlands
Degradation of extracellular matrix (ECM) and adhesion of tumor cells to and detachment from other tumor cells and from the ECM are key steps in tumor invasion and metastasis. These processes all depend on coordinated expression of proteolytic enzymes and adhesion molecules. Various studies have analyzed the crucial role of matrix metalloproteinases (MMPs), their specific tissue inhibitors (TIMPs), and molecules that regulate their expression and/or activation in melanocytic tumor progression. Recent results have indicated that adhesion molecules such as integrin avb3 and CD44 are involved in positioning activated MMP molecules on the cell surface of invasive tumor cells. This review evaluates the role of MMPs and TIMPs, and the interactions between individual MMPs and cell adhesion molecules in human melanoma.