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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Aste Nicola, Pau M., Aste Natalia, Biggio P.
Università degli Studi - Cagliari Clinica Dermatologica
Pyoderma gangrenosum is a chronic inflammatory ulcerative skin disease of unknown etiology, often associated with various systemic disorders such as inflammatory bowel disease, rheumatoid arthritis and myeloproliferative disorders. Pyoderma gangrenosum as four distinctive clinical and histologic variants: ulcerative, pustular, bullous and vegetative. In addition to different clinical appearances, rates of progression, and associated systemic diseases, the histopathologic changes can vary considerably in each of these types. Management of the disease depends on its type and severity. Corticosteroids are the mainstay of therapy. Nine cases of Pyoderma gangrenosum, 7 males on 2 females, observed from 1990 to 2000 at the Department of Dermatology of the Cagliari University are described. Their mean age was 58 years (range 34-83). The lower legs presented the typical site. Seven patients had ulcerative variant, one patient had bullous form and one had vegetative pyoderma. Two patients had ulcerative colitis and three patients, respectively, rheumatoid arthritis, asthmatic bronchitis and diabetes mellitus, gastrectomy for gastric ulcer and chronic obstructive pulmonary disease. Some epidemiological, clinical and therapeutical observations are presented as a contribution to the knowledge of such an uncommon disease.