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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2001 April;136(2):153-6

language: Italian

Mycosis fungoides with histological appearance of pagetoid reticulosis

Ghislanzoni M., Gambini D., Alessi E., Berti E. *

IRCCS Ospedale Maggiore - Milano Istituto di Scienze Dermatologiche
*Università degli Studi - Milano Bicocca


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The authors report the case of a 76-year-old man affected by clinically typical mycosis fungoides. Histological analysis throughout the course of the disease highlights an exclusively intra-epithelial infiltrate consisting of CD45RO+, CD3+, CD4+, CD103/HML-1+ lymphocytes with a rearranged T-cell receptor gamma chain. This unusual histological finding recalling pagetoid reticulosis can possibly be explained by the persistent positivity for aEb7 integrin highlighted by the monoclonal antibody CD103/HML-1. This integrin, which is physiologically expressed by intraepithelial lymphocytes and some localized in the lamina propria of the small intestine, is responsible for intraepidermal T-lymphocyte localization in early mycosis fungoides and is usually lost, together with epidermotropism, during the course of illness. In this patient it was, for reasons that are not clear, persistently and intensely expressed with a consequent and constant neoplastic infiltration only at an intraepithelial level.

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