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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Pezzarossa E., Lazzari G. B.
Azienda Istituti Ospitalieri di Cremona Divisione Dermatologica
Acute hemorrhagic edema or Finkelstein disease, a distinctive expression of leukocytoclastic vasculitis, is characterised by tender edema and ecchymotic purpuric skin lesion with a target-like or cockade pattern. Despite the important skin lesions, the course of the disease is generally uneventful. Its cause is unknown, although the increased frequency during winter months and the association with upper respiratory tract infections, vaccination or antibiotic therapy prior to the onset of eruption suggest that AHE could be mediated by immune complexes generated in response to infectious agents or drugs. Two cases of Acute Hemorragic Edema of Childhood (AHE) observed during four years are presented. AHE in these patients arose after an upper respiratory tract infection treated with antibiotics. Histopathological examination demonstrates a leucocytoclastic vasculitis. The complete resolution occurred in about three weeks and follow-up was negative. The main importance of this infrequent disorder is to differentiate it from other vasculitis that require an effective treatment, particularly Schonlein-Henoch Purpura.