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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2000 August;135(4):505-8
Linear basal cell carcinoma. A case report and review of the literature
Amerio P., Guzzo T., Verdolini R., Giangiacomi M *., Amerio P. **, Giornetta L.
Università degli Studi - Ancona Clinica Dermatologica e * Dipartimento di Anatomia Patologica Ospedale Regionale di Torrette
** Clinica Dermatologica, Policlinico «A. Gemelli» - Roma
Basal cell carcinoma is one of the most frequent human malignancies. Environmental more than hereditary factors may play a role in its pathogenesis. Apart from the well recognized clinical variants: superficial, nodular and infiltrative morphoea-form numerous other clinicopathological subtypes of basal cell carcinoma have been reported: fibrous (fibroepithelioma of Pinkus), cystic, multifocal, giant (which is subdivided into four histologic subtypes), keloidal, and more recently polypoid. Linear basal cell carcinoma was first described by Lewis in 1985. The case of a 75 year-old man presenting a linear lesion on the supraclavicular region, arisen 5 years previously, 5 cm long with elevate borders and covered by crusts is described. The patient referred repeated scratching of the lesion. Microscopical examination revealed an infiltrative proliferation of large cells. The typical palisade cell wall was present throughout the infiltrative border of the neoplasia. A dense deposition of fibrous connective tissue was present around the infiltrative neoplas. Diagnosis of linear infiltrative basal cell carcinoma was performed. Linear basal cell carcinoma is more aggressive than standard basal cell carcinoma thus requiring a particular attention in the diagnosis and a more radical therapy. A discussion on the hypotheses on the pathogenesis of the linear morphology of this subtype of basal cell carcinoma is presented.