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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Aste N., Pau M., Loddo G., Biggio P.
Università degli Studi - Cagliari Clinica Dermatologica (Direttore: Prof. P. Biggio)
Sweet’s syndrome, an acute febrile neutrophilic dermatosis, is characterized by the acute appearance on face, neck, chest and extremities of tender erythematous plaques and nodules, usually accompanied by fever, generalized weariness and neutrophilic leucocytosis. The histopathologic analysis shows dense dermal neutrophilic infiltrates, frequent leukocytoclasia without vasculitis. Typical feature is also the extreme sensibility to systemic corticosteroid therapy. Associated malignancy occurs in approximately 10-15% of cases. The vast majority of malignancies are hematopoietic, and particularly myeloproliferative disorders can be observed. Ten cases of Sweet’s syndrome, 4 males and 6 females, observed from 1988 to 1999 at the Department of Dermatology of the Cagliari University are described. In nine cases no other associated pathologies were observed, and in one case a necrotizing granulomatous lymphadenopathy was present. Some epidemiological, clinical and therapeutical considerations are presented as a contribution to the knowledge of such an uncommon disease.