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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
From the Dermatology Clinic, University Hospital Hôpital Edouard Herriot, Lyon, France
Leukocytoclastic vasculitis (LV) is a hypersensitivity vasculitis, similar in nature to the experimental Arthus reaction. The immune complexes circulate until some event occurs that cause deposition in blood vessel walls. Adhesion molecules and cytokines released by endothelial cells and activated neutrophils represent a key factor in this process. The membrane attack complex of complement plays a significant role in altering endothelial cell membrane integrity. Activated neutrophils release proteolytic enzymes, especially collagenases and elastases, along with free oxygen radicals that damage the vessel walls and the surrounding tissues. In conclusion, the post-capillary venule is the active orchestrator of neutrophils in LV that mediates a complex series of endothelial/leukocyte interactions.