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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2000 August;135(4):427-31
Photodynamic therapy of primary and secondary (non-melanoma) skin tumors with topical delta-aminolevulinic acid
Pinzi C., Campolmi P., Moretti S. *, Guasti A. **, Rossi R., Cappugi
Università degli Studi - Firenze U. O. Fisioterapia Dermatologica
* U. O. Dermatologia II Dipartimento di Scienze Dermatologiche
** U. O. Fisica Sanitaria Azienda Ospedaliera Careggi - Firenze
Background. The aim of the paper is to investigate the clinical response and the possible side effects of the photodynamic therapy of primary and secondary (non-melanoma) skin tumours with topical delta-aminolevulinic acid.
Methods. The study has been carried out on 93 patients for a total of 101 non-melanoma skin tumours and 23 actinic keratoses treated with topical O/W emulsion containing 5-aminolevulinic acid (ALA) 20% under occlusive dressing for 20-24 hours before irradiation with 630 nm light. Pictures of the lesions have been taken before and after therapy. On the major part of the lesions a biopsy has been made before and after therapy. The lesions were followed-up every 6 months.
Results. Complete response was observed in 63 superficial basal cell carcinomas (BCCs) (82%), 5 nodular BCCs (55%), 23 actinic keratoses (100%) after only one ALA application. Partial response was observed in 14 superficial BCCs, 4 nodular BCCs, 2 kaposi’s sarcoma, 2 nodular lung cancer metastases and 1 squamous cell carcinoma (SCCs). Moreover, 4 cutaneous indolent B-cell Lymphoma (CBCL) and 6 breast cancer metastases have also been treated with complete response (100%) after one or two application.
Conclusions. The results obtained show that photodynamic therapy (PDT) with ALA is an effective alternative treatment of primary and secondary non-melanoma skin tumours.