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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2000 June;135(3):383-6

language: English

Unusual features of sebaceous carcinoma in a typical Muir-Torre syndrome

Donati P., Ferraro M. C. *, Bellocci M. **, Muscardin L. M.

From the San Gallicano Hospital, Rome Laboratory of Dermatopathology
* Department of Dermatology
** Laboratory of Ultrastructure


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A typical Muir-Torre syndrome in two brothers, with different kind of sebaceous tumor in their skin is described. In one of the two brothers an unusual giant primary subcutaneous poorly differentiated sebaceous tumor of the back is observed, until now rarely reported in cutaneous sebaceous tumors in the course of a Muir-Torre syndrome (MTS). The patient is alive and well after a 5-year follow-up, confirming the low malignancy of neoplasms in MTS. The particular histologic features are described, and differential diagnosis with a cutaneous metastasis of visceral tumor is discussed. The implication of the diagnosis of Muir-Torre syndrome reflects a careful study of the patients in order to exclude any visceral neoplasm, including examination of the relatives.

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