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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
D’Avino M., Guerrera V., Pinto F., Lo Schiavo A.
Seconda Università degli Studi - Napoli Facoltà di Medicina e Chirurgia Clinica Dermosifilopatica (Direttore: Prof. V. Ruocco)
The pemphigus-neoplasia association is a well-known topic but it is also an open question. A literature review of cases of pemphigus-neoplasia association from 1936 to 1998 is presented. The mere association, the possible etiopathogenic correlations or the existence of a true syndrome are considered. Thymoma and lymphoreticular neoplasms are the most frequently associated tumors. Clinical and pathogenic aspects of the neoplasia-associated pemphigus do not differ on the whole from those characterizing the form not associated with a tumour. However, in 1990, Anhalt described a distinct autoimmune vesicobullous disorder with peculiar clinical and histological features (overlapping pemphigus and erythema multiforme), associated with lymphoreticular neoplasms, which he termed paraneoplastic pemphigus.