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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2000 June;135(3):315-21
Efficacy of a new cosmetic product for cutaneous xerosis: results of a corneometric evaluation
Mei S., Amato L. E., Gallerani I., Perrella E., Melli M. C., Fabbri P.
Università degli Studi - Firenze Dipartimento di Scienze Dermatologiche Clinica Dermatologica II (Direttore: Prof. P. Fabbri)
Background. Cutaneous xerosis is a frequent clinical pattern, caused by an altered barrier function of the horny layer. In this clinical condition skin is dry, rough to the touch, with a little desquamation. Aim of this paper is the evaluation of the moisturising capacity of a cosmetic product containing ceramides 0,2% and other active constituents (particularly urea and lactic acid).
Methods. The study has been carried out in a group of 17 patients with different kinds of cutaneous xerosis and in a control group of 7 healthy subjects of the same age and sex, with a corneometer (CM420) evaluation. Corneometer measurement on the forearm was executed and the cutaneous hydratation 30, 60, 180 minutes after the application of the cosmetic product and was controlled.
Results. This product was able to increase with statistical significance the corneometer values in the examined cutaneous area, both in xerotic patients and in case-control subjects after only 30 minutes. These values were still statistically significant after 180 minutes.
Conclusions. This preliminary research shows that the significant moisturising capacity of the cosmetic product studied, is probably related to the presence of ceramides and lactic acid, which are able to stimulate, in vivo and in vitro, keratinocytes’ ceramides synthesis.