Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2) > Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2):223-7

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,311


eTOC

 

CLINICAL CASES  


Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2):223-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

Pyogenic granuloma induced by cyclosporin A. Comments on 4 cases

Ena P., Leigheb G. *, Retanda G., Marras V. **

Università degli Studi - Sassari Clinica Dermatologica * Università degli Studi - Novara Clinica Dermatologica «A. Avogadro» ** Università degli Studi - Sassari Istituto di Anatomia Patologica


PDF  


The most frequent collateral effects observed during cyclosporin A (CyA) treatment take the form of systemic manifestations linked to hepatonephrotoxicity, neurotoxicity, chronic infection or benign proliferative cutaneous and mucosal lesions (gingival hyperplasia, multiple keratosis, facial papilloma, periungual granuloma). The collateral effects observed in transplanted patients do not differ from those reported during treatment for skin disorders (severe psoriasis, lichen planus). Three patients (2 females, 1 male), aged 64, 55 and 52 years old respectively, suffering from erosive Lichen planus of the moral mucosa and one patient with severe chronic atopic dermatitis showed the onset of ectophytic lesions, respectively in intraoral and cutaneous localisations, during prolonged cyclosporin treatment at an average dose of 3 mg/kg. Histological and immune histochemical tests revealed a pyogenic granuloma with a large plasmacellular component in all 3 patients with oral lesions. The histochemical analysis of all three patients confirmed the normosecretion of Ig. No recurrence was observed after an average of 18 months after the exeresis of lesions. These cases are reported owing to the singularity of the collateral effects induced by the drug, and their analogy with other proliferative processes described during the course of immunosuppressive treatment with Cyclosporin (gingival hyperplasia, Kaposi’s sarcoma). The authors believe that the immunosuppression induced by CyA may encourage the onset of pyogenic granuloma as well as lymphoproliferative disorders probably caused by infectious agents.

top of page

Publication History

Cite this article as

Corresponding author e-mail