Advanced Search

Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2) > Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2):217-21

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEGIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820

 

Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2):217-21

    CLINICAL CASES

Reticular erythematous mucinosis syndrome (REM syndrome). Case report and therapeutical response to hydroxychloroquine sulfate

Brazzelli V., Chiesa M. G., Baldini F., Vassallo C., Ardigò M., Rosso R. *, Borroni G.

Università degli Studi - Pavia Policlinico S. Matteo IRCCS - Pavia Dipartimento di Patologia Umana ed Ereditaria Clinica Dermatologica
* Istituto di Anatomia Patologica

Reticular erythematous mucinosis (REM) syndrome is a rare, chronic disease characterized by asymptomatic, persistent reticular, slightly infiltrated erythematous plaques on chest and/or back with slight infiltration. Mild itching may be associated. At present, almost 100 patients with REM syndrome have been described. The case of a young woman with a pruritic, erythematous, reticular plaque on her back, worsened by sun exposure is described. Clinical and laboratory data were in the normal range or negative, the skin biopsy demonstrated the presence of mucin among collagen bundles and around blood vessels and adnexa; perivascular and periadnexial lymphocytic infiltration was present. Alcian blue pH 2.5 staining was strongly and diffusely positive. Direct immunofluorescence of the skin biopsy revealed the deposition of IgA, IgM, and fibrin around the papillary blood vessels, and complement at the dermoepidermal junction. Electron microscopy showed granular and filamentous material between the collagen fibres. All these features were consistent with a diagnosis of REM. Treatment with hydroxychloroquine sulfate 400 mg/day for a month and successively 200 mg/day, carotenoids and sun-screen creams resulted in a complete resolution of REM lesions. No recurrence of REM was seen at one year follow-up examination.

language: Italian


FULL TEXT  REPRINTS

top of page