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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2000 April;135(2):195-9
Cutaneous CD30+ (Ki-1) lymphoma: pathological classification and description of two cases
Passarini B., Bandini P., Zinzani P., Varotti C.
Università degli Studi - Bologna Dipartimento di Medicina Clinica Specialistica e Sperimentale Istituto di Dermatologia e Venereologia (Direttore: Prof. C. Varotti)
Istituto di Ematologia e Oncologia Medica Seragnoli (Direttore: Prof. S. Tura)
Skin CD30+ lymphomas include a broad range of pathologies, such as lymphomatoid papulosis (LyP) and Anaplastic Large Cell Lymphoma (ALCL). The CD30 positive reaction is simply due to the lymphocyte activation and it may be related to benign skin eruption or in mycosis fungoides: such a positive reaction is not sufficient to make a diagnosis of lymphoproliferative syndrome. ALCL is a highly malignant skin lymphoma, present at any age, it may arise as primary skin lesion (more frequent in adult with better prognosis) or as a systemic form (more frequent in children and with a more severe prognosis). The skin lesions are represented by few nodular lesions developing as ulcers, with histology showing dermal and ipodermal infiltrates, mainly made of large lymphocytes with nuclear atypia and frequent mitoses. Two cases are described: a 56-year old male and a 25 year-old female; for both patients the diagnosis was reached after repeated admissions and histological examinations in different hospitals. After repeated chemotherapy and radiotherapy treatments, the male died due to the high malignancy of the lymphoma which was systematically diffused (liver, lungs).