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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Manfredi G., Naldi L.
Università degli Studi - Milano Clinica Dermatologica V Ospedali Riuniti - Bergamo
Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis: a nosografic review.
The classification of erythema multiforme major (EMM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has always been a much-discussed problem. The aim of this paper is to present a recently developed classification of EMM-SJS-TEN taking into account: 1. type of elementary lesions; 2. distribution of lesions; 3. extent of the dermo-epidermal detachment. Five diagnostic categories have been identified including: 1. EMM characterized by typical target lesions or raised atypical target lesions mainly located on limbs, skin detachment less than 10%, mucosal involvement; 2. SJS characterized by widespread flat atypical target lesions or spots, skin detachment less than 10%, common mucosal involvement; 3. overlap SJS-TEN characterized by widespread flat atypical target lesions or spots, skin detachment from 10% to 30%, common mucosal involvement; 4. TEN characterized by spots and extensive skin detachment involving more than 10% of the body surface area; 5. TEN without spots.