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A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2000 February;135(1):107-14

language: Italian

Treatment of psoriasis with an antiseptic combination, in a double-blind comparison versus Eosin

Leigheb G., Gallus D., Spano G.

Università degli Studi - Sassari Clinica Dermatologica (Direttore: Prof. G. Leigheb)


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Background. Eosin, in 2% water solution, is frequently emplo-yed in the topical treatment of psoriasis. The study had the purpose of checking if the 2% eosin-0,3% chloroxylenol combination, in water-glycol solution, caused different effects versus those of 2% eosin solution in the treatment of psoriasis.
Methods. To this purpose, 40 patients of both sexes were recruited. Their age ranged from 8 to 74 years. They were suffering from inverse psoriasis (psoriasis of the skin folds) in active phase, generally combined with psoriasis in the classical sites. The patients’ population was randomised into two groups of 20 patients each, treated separately with one daily application of the two antiseptic solutions for 2 to 4 weeks.
Results. Eosin-chloroxylenol combination was found to be effective, since it caused a progressive improvement of the symptoms till their remission in the majority of patients, without clinical or statistical differences versus eosin (P>0.05). However, the antiseptic combination showed a faster activity on inverse psoriasis than the reference preparation. Indeed at the end of the first week of therapy, the rates of remission obtained with the combination were clinically and statistically higher (P<0.01) and reached a mean reduction of 2 days in the period of treatment.
Conclusions. The therapeutic efficacy of the combination, accompanied by an excellent drug safety, allows to use the preparation also in chronic or recurrent treatments on wide skin surfaces, such as in psoriasis.

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