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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2000 February;135(1):101-5
Clinical and instrumental evaluation of the efficacy of a vasoactive drug containing vitamin PP, vitamin C and phyto-therapeutic extracts titrated in escin, bromelain and anthocyanosides for the treatment of varicose leg ulcers
Turio E., Romanelli M., Barachini P.
Università degli Studi - Pisa Sezione Dermatologia e Venereologia Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia
Background. Chronic leg ulcers due to venous insufficiency represent a significant burden for the national sanitary system. Although the role of venous hypertension as a key pathogenetic factor of this lesion is clear, several microcirculatory mechanisms involved in the tissue repair process remain to be clarified. The purpose of this study was to evaluate the efficacy and tolerability of a vasoactive drug for the treatment of varicose leg ulcers.
Methods. The study was a prospective randomized trial lasting eight weeks. Twenty patients matched for sex, age, wound dimensions and with clinical and instrumental evidence of chronic venous insufficiency were enrolled in this study. Patients attended a weekly consultation at the outpatients clinic for chronic leg ulcers of the Department of Dermatology at the University of Pisa and they were randomized into two groups according to treatment: G1 (n=10) vasoactive drug, occlusive dressing, elastic bandage, G2 (n=10) occlusive dressing, elastic bandage. During the study, subjective parameters were evaluated: intensity of pain, paresthesia, heaviness and objective parameters: intensity of oedema, wound area, transcutaneous tissue gas monitoring (O2 - CO2).
Results. At the end of the study a marked reduction of subjective symptoms such as pain and paresthesia was observed with an increase of oxygen tissue perfusion in the G1 group compared to the G2 group. No significant differences were observed in the two groups about the remaining parameters investigated.
Conclusions. The drug investigated in this study showed a good tolerability and efficacy in weakening the clinical symptoms related to venous insufficiency. The positive effect of the vasoactive drug on transcutaneous oxygen tension confirms a direct action on the microcirculatory system, which could positively modulate the tissue repair process.