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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):631-4
Churg-Strauss syndrome. A case report and its follow-up
Farris A. 1, Micalizzi C. 1, Cavaleri M. 3, Vacca N. 2, Barabino G. F.
1 Ospedale S. Paolo - Savona, Divisione di Dermatologia;
2 Ospedale S. Paolo - Savona, Medicina Interna I;
3 Ospedale di Albenga (Savona), Divisione di Dermatologia
The authors describe a typical case of allergic granulomatous angiitis (Churg-Strauss syndrome) observed in a 32-year-old woman suffering from asthma and rhinitis. The cutaneous manifestations appeared on limbs and the scalp a few years after the aforesaid symptoms and took the form of erythematous and papular lesions confluent into plaques and showing a tendency to ulceration. Histological analysis showed a conspicuous granulocytic and mainly eosinophilic widespread infiltration around the blood vessels of the derma and infiltrating the vascular wall. Leucocytoclasis and necrosis were present. Chest X-ray showed a typical picture of “ground glass” interstitial disease that was confirmed by lung CT, whereas the X-ray of the paranasal sinuses revealed a slight, veiling of the frontal sinuses due to the thickening of the mucosa. The diagnosis was ascertained on the basis of all these clinical, histological and instrumental data. Steroid treatment initially at a high dose followed by a gradual reduction led to the complete resolution of dermatological and lung symptoms and no recidivation was observed at the follow-up two and a half years later.