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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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CASE REPORT  


Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):631-4

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Churg-Strauss syndrome. A case report and its follow-up

Farris A. 1, Micalizzi C. 1, Cavaleri M. 3, Vacca N. 2, Barabino G. F.

1 Ospedale S. Paolo - Savona, Divisione di Dermatologia; 2 Ospedale S. Paolo - Savona, Medicina Interna I; 3 Ospedale di Albenga (Savona), Divisione di Dermatologia


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The ­authors ­describe a typ­i­cal ­case of aller­gic gran­u­lom­a­tous ­angiitis (­Churg-­Strauss syn­drome) ­observed in a 32-­year-old wom­an suf­fer­ing ­from asth­ma and rhin­itis. The cuta­ne­ous man­i­fes­ta­tions ­appeared on ­limbs and the ­scalp a few ­years ­after the afore­said symp­toms and ­took the ­form of ery­them­a­tous and pap­u­lar ­lesions con­flu­ent ­into ­plaques and show­ing a ten­den­cy to ulcer­a­tion. His­to­log­i­cal anal­y­sis ­showed a con­spic­u­ous gra­nu­lo­cyt­ic and main­ly eosin­o­phil­ic wide­spread infil­tra­tion ­around the ­blood ves­sels of the der­ma and infil­trat­ing the vas­cu­lar ­wall. Leu­coc­y­toc­la­sis and necro­sis ­were ­present. ­Chest X-ray ­showed a typ­i­cal pic­ture of “­ground ­glass” inter­sti­tial dis­ease ­that was con­firmed by ­lung CT, where­as the X-ray of the par­a­na­sal sinus­es ­revealed a ­slight, veil­ing of the fron­tal sinus­es due to the thick­en­ing of the muco­sa. The diag­no­sis was ascer­tained on the ­basis of all ­these clin­i­cal, his­to­log­i­cal and instru­men­tal ­data. Ster­oid treat­ment initial­ly at a ­high ­dose fol­lowed by a grad­u­al reduc­tion led to the com­plete res­o­lu­tion of der­mat­o­log­i­cal and ­lung symp­toms and no recid­i­va­tion was ­observed at the fol­low-up two and a ­half ­years lat­er.

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