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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):627-30
Multiple keratoacanthomas in chronic renal failure. Case report
Scavo S., La Rocca R.
Università degli Studi - Catania, Clinica Dermatologica
The keratoacanthoma is a benign nodular lesion of epidermic derivation (high part of the hair follicle). The unilesional form is generally self-healing within a month. Multilesional forms are rare, they do not often tend to resolve and can be found in any skin part also in mucous membranes. A case of multiple keratoacanthomas that appeared for some years in a habitual seventy-two year old smoker is described. In his early life he had many years exposure to sun and immunodeficiency. He was afflicted by chronic renal failure together with an insistent pruritus and continuous scratching. After a discussion about a differential diagnosis with various forms of multiple keratoacanthomas, different pathogenetic hypothesis of chemical and physical type were taken into consideration: phototraumatology, mechanical trauma for scratching in a subject with uremic pruritus and the irritating effects of pitch and tar. Therapy with retinoid was carried out for little more than a month and the result was a regression of some lesions, but it was necessarily stopped because of some complications which arose. Finally, it is pointed out, as in this case, how skin can be considered an organ that gives evidence of internal pathologies.