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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):623-6

language: Italian

Eccrine syringofibroadenoma. A case report

Pestarino A. 1, Dezzana M. 2, Piccini R. 1, Tunesi G. 2

1 EO Ospedali Galliera - Genova, Divisione di Dermatologia;
2 Servizio di Istologia e Anatomia Patologica


A 65-year-old woman attended our department for treatment of a persistent, slowly growing, erythematous plaque of her left foot. In the last months a slighty ulcerated, tender, nodule had apperared in the center. Histopathology showed an epidermal proliferation of thin strands of small cuboidal cells, extending to the medium dermis. These strands, which tended to form anastomosis, contained ductal structures and cystic spaces. The stroma showed increased vascularity and a scarse infiltrate composed by lymphocytes, some plasma cells and numerous mast cells. Eccrine syringofibroadenoma is a rare entity characterized by various clinical features: multiple papules, plaques or a solitary nodule, mostly localized on the extremities. The last classification of eccrine syringofibroadenoma consists of the following subtypes: 1) solitary, 2) multiple, familial with hidrotic ectodermal dysplasia (Schopf syndrome), 3) multiple non familial without associated cutaneous findings and 4) non familial, unilateral and linear or nevoid eccrine syringofibriadenoma. Some cases are closely associated with specific dermatosis (inflammatory o neoplastic) following recurrent eccrine duct lesions forming a new subtype, namely reactive eccrine syringofibroadenoma. The histogenesis is still a matter for debate: most authors consider eccrine syringofibroadenoma derived from acrosyringium; recently an origin from the intradermal portion of the eccrine duct has been proposed. The role of mast cells is not known.

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