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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Brunetti R., Cervadoro G.
Università degli Studi - Pisa, Clinica Dermatologica
Background. The mechanism of action of D3 vitamin, represented by the inhibition of the keratinocytes proliferation and of wide immunomodulatory activity, suggests the rational for their use also in keratinization disorders; in fact, these pathologies show clinical-histological findings characterized by hyperkeratosis accompanied by inflammatory phenomena at the dermal level. The aim of the study was to assess the efficacy of calcipotriol, a synthetic D3 derivative employed in psoriasis therapy, on a series of patients suffering from different types of dyskeratosis.
Methods. This open study was carried out by the Dermatological Department of the University of Pisa; out-patients were enrolled. The treatment consisted of calcipotriol ointment (50 µg/g) applied twice a day. The duration of treatment was related to the clinical improvement of the lesions. Twenty-height patients (9 M; 19 F) aged between 40 and 85 years suffering from actinic porokeratosis (5 cases), Mibelli’s porokeratosis (3 cases), actimic keratosis (15 cases) palmo-plantar hyperkeratosis (2 cases), ichtyosis (1 case), chronic likenified eczema (1 case), verruca vulgaris hyperkeratotic (1 case). At the fortnightly/monthly visits, photographs of the treated lesions were taken and any adverse effects occurred were recorded. The treatment lasted 6.5±0.7 weeks (range 3-7).
Results. Lesions presented by patients suffering from porocheratosis, palmo-plantar hyperkeratosis, chronic likenified eczema, verruca vulgaris hyperkeratotic disappeared while good clinical improvement was assessed by the remaining patients with reduction of the hyperkeratotic margin.
Conclusions. This study is the first approach to the evaluation of topical calcipotriol in the treatment of cutaneous diseases different from psoriasis. Further studies will be necessary.