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Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4) > Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4):395-7



A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820


Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4):395-7


Clinical study of the activity of hafnia biolysate in acne vulgaris

Rigoni C., Toffolo P., Spinelli G.

Università degli Studi - Milano, IRCCS Ospedale Maggiore, Istituto di Scienze Dermatologiche

Background. Hafnia biolysate, a water-soluble extract obtained from Enterobacter hafnia cultures, has a remarkable anti-inflammatory activity which is also confirmed by the inhibition test on the migration of polymorphocytes from derma-capillaries. This active principle has been used for the production of cosmetics specific for the treatment of cutaneous irritation and in particular as cosmetic adjuvant in the treatment of acne.
Methods. On this basis, an open clinical study has been carried out to evaluate the activity, the tolerability and the cosmetic acceptability of the anti-irritant Cream containing hafnia biolysate for one month in the treatment of irritative dermatitis caused by anti-acne remedies. Forty patients were chosen, aged between 13 and 30 years, whose acne lasted from at least 1 month to a maximum of 14 years. All the patients had facial acne; 4 patients had lesions on the thorax and the back. At the start of treatment all patients were in therapy with anti-acne remedies.
Results. At the end of treatment the anti-irritant action of the cream has been considered very good in 27 cases, good in 6 cases, moderate in 5 cases, low in 1 case and useless in 1 case. No side effects have been noted.
Conclusions. The results lead us to consider this cream an effective complement in acne therapy to prevent or limit irritative dermatitis produced by anti-acne remedies. The hafnia biolysate cream, formulated from innovative research and directed specifically to those patients affected by acne under medical therapy, was well tolerated in this study and demonstrated a soothing action on local inflammation and xerosis produced by anti-acne treatments.

language: Italian


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