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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4):391-4
Efficacy and tolerability of a topical product containing chlorhexidine gluconate 0.1% and allantoin 1% in the treatment of skin lesions and ulcers
Brambilla L., Boneschi V.
IRCCS Ospedale Maggiore di Milano Istituto di Dermatologia
Background and aim. The use of a wide spectrum antiseptic with good tolerability may encourage the healing of broken skin resulting from minor surgery and ulcers. The efficacy and tolerability of a topical product containing chlorhexidine, an antiseptic with a marked antibacterial capacity, and allantoin, offering hydrating and keratolytic properties which foster the development of granulation tissue.
Methods. An open retrospective study was carried out in 30 patients, 16 males and 14 females aged between 12 and 82 years old, with skin lesions caused by minor outpatient surgery, like curettage and diathermocoagulation (23 patients), lower limb chronic venous insufficiency (5 patients) or the action of external agents (2 patients). Enrolment in the study was random. The product was applied twice a day and results were inspected weekly or twice weekly. The clinical aspects of lesions and the extent of re-epithelialisation were assessed. A total of 29 patients were evaluated.
Results. All the lesions healed within a period of between 1 and 8 weeks, without signs of bacterial infection. Tolerance and patient compliance were good.
Conclusions. The use of a topical compound containing chlorhexidine and allantoin proved effective in avoiding infection and encouraging the healing process in the skin lesions examined in this study.