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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4):283-8
Contact X-ray therapy versus soft X-ray therapy in the treatment of extensive basal and squamous cell carcinomas of the skin
Caccialanza M., Piccinno R., Beretta M., Gnecchi L.
Department of Photoradiotherapy, Institute of Dermatological Sciences, University of Milan, Ospedale Maggiore, IRCCS, Milan, Italy
Background. On the basis of the favourable therapeutic response of radiotherapy in the treatment of extensive skin carcinomas, to state which radiological technique yields the best results as regards cure-rate, the cosmetic response and the lack of sequelae is of practical interest. To this aim a retrospective study was performed in two groups of patients respectively treated with contact X-ray therapy (CxRT) and soft X-ray therapy (SxRT) in the period 1982-1996.
Methods. One hundred and nineteen patients affected by 132 histologically ascertained lesions were studied (93 basal cell carcinomas, 37 squamous cell carcinomas, 2 metatypic cell carcinomas). Seventy-two lesions underwent CxRT and 53 SxRT. The total doses administered ranged from 50 to 70 Gy for CxRT and from 50 to 65 Gy for SxRT, fractionated in two weekly doses of 5 Gy each.
Results. The mean follow-up of the series of patients treated with CxRT was 25.87 months, while that of patients treated with SxRT was 33.95 months. The five-year cure-rate after radiotherapy was 82.04% for the series of patients treated with CxRT and 78.91% for the series of patients treated with SxRT. The cosmetic results were evaluated as good or acceptable in 95.83% of cases treated by CxRT and in 72.33% of those treated by SxRT. Chronic radiodermatitis (1.88%) occurred in a patient who had underwent SxRT.
Conclusions. The results obtained show that, when the size of the lesion is suitable for this technique, CxRT performed with multiple juxtaposed fields may be executed with a therapeutic and cosmetic response which is better than that obtained by SxRT.