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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1999 June;134(3):201-5
Glycolic acid and kojic acid. A new combined treatment
Cotellessa C., Mazzocchetti G., Giacomello R., Peris K., Chimenti S.
Università degli Studi - L’Aquila, Clinica Dermatologica
Background. Cutaneous hypermelanoses of the face and neck represent a common cutaneous disorder which therapy generally requires a long time and is often unsuccessful. Recently, in dermatological treatment of hypermelanosis a new whitening agent, kojic acid has been introduced. It is an antibiotic produced by many fungal species with excellent depigmenting properties that seem to be related to the specific inhibition of the enzyme tyrosinase. The aim of this study was to evaluate the efficacy and tolerability of a combined treatment with glycolic acid and kojic acid in patients with cutaneous hypermelanosis.
Methods. 12 female patients with cutaneous hypermelanosis of the face were treated with a gel solution of 50% glycolic acid and 10% kojic acid, applied on the whole face for 10-15 minutes and then washed out. In all patients the treatment was repeated weekly for a total period of 3-6 months.
Results. Complete regression has been observed in 3/12 patients (25%) and partial regression has been achieved in 8/12 cases (67%). No regression has occurred in 1/12 cases (8%). No side effects have been observed.
Conclusions. The efficacy of the combined treatment with glycolic acid and kojic acid at high concentrations and its tolerability lead to consider it a valid therapeutic alternative in the treatment of cutaneous hypermelanosis.