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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Celleno L., Mastroianni A., Borgia M. G., Cerimele D.
Università Cattolica del S. Cuore - Roma, Istituto di Clinica Dermatologica
Kaposi’s sarcoma is usually classified as a connective-vascular tumour of polycentric origin whose pathogenesis and clinical development are regulated by immunological factors. It mainly affects the skin and mucous membranes, from an epidemiological, clinical and evolutive point of view, Kaposi’s sarcoma can be divided into four different forms: the classic or sporadic one, the african or endemic form, the epidemic or AIDS-related form and the iatrogenic form observed in patients immunosuppressed because of organ transplants. In histological terms, Kaposi’s sarcoma is characterized in the early stages by the appearance of newly-formed irregular vessels (especially in the perivenular region), occasionally accompanied by an increase in the number of spindle-shaped nuclei. At the advance stage, typical histological results reveal bundles of interwined spindle-like cells.