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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Aste N. 1, Baldari U. 2, Bellini M. 3, Biggio P. 1, Pinna A. L. 1, Pau M. 1, Pavone P. S. 4, Righini M. G. 2, Vallecchi C. 3
1 Università degli Studi - Cagliari, Clinica Dermatologica;
2 Ospedale «G. B. Morgagni» - Forlì, Divisione di Dermatologia;
3 Università degli Studi - Firenze, Clinica Dermatologica;
4 Ospedale Generale di Zona - Menaggio (Como), Ambulatorio di Dermatologia
Efficacy and safety of the topical formulation of fluconazole 0.5% (gel containing an emulsion oil/water o/w) in the treatment of dermatomycoses with localized lesions: Results of a multicenter, open, non comparative study.
Background. Dermatophytoses are a group of diseases caused by keratinophilic mycetes involving the skin and its adnexa. At present, there is a wide range of antimycotic drugs which may be used by topical and systemic route with very good results and mild side-effects.
Methods. Seventy-one patients, 37 males and 34 females, age range 6-81 years, with Tinea corporis, Tinea cruris, Tinea pedis from dermatophytes or candida were treated with topical fluconazole 0.5%. The drug was applied once daily for an average period of 21±6 days.
Results. Fifty-seven patients completed the treatment and at the last follow-up 94% of them was completely cured and 6% improved. The therapeutic efficacy of topical fluconazole 0.5% resulted almost equivalent in the 3 groups: 96% of cure in patients with T. pedis, 93% in patients with T. corporis and 100% in those with T. cruris. The tolerability, both general and local, was good in 97.2% and 93% of cases, respectively. In only two cases mild and transient side effects occurred.
Conclusions. These results confirm that fluconazole, also in this new topical formulation 0.5%, is an innovative molecule, with a great antifungal potency and an excellent local tolerability.