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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Stradini D. 1, Gambini C. 2, Desirello G. 1, Crovato F. 1
1 Ospedali Riuniti USL 4 - Chiavari, Divisione Dermatologica ;
2 Istituto Gaslini - Genova, Servizio di Anatomia Patologica
Background. The aim of this work was to verify the incidence and peculiarities of an unusual clinical picture in silversmiths, previously described in the literature in a case with blue nevi-like lesions.
Methods. A wide clinical research has ben made at Campoligure (the cradle of silver filigree manifacture in Italy): 65 silversmiths have been considered on the whole. In a case, a skin biopsy removed a big lesion of the thigh.
Results. In more than half the cases, the presence of blue nevi-like lesions have been noticed; the seats more often involved were hands and forearms, and the size of the lesions varied from few millimeters up to half centimetre the most. The biopsy confirmed a picture of localized occupational argyria.
Conclusions. The review of the literature on this subject has permitted to better define its histogenesis and to point out its main interest. In the fact, a few microns microsplinter of silver filigree can produce skin lesions up to half centimeter large, due to a process of centrifugal elimination of metal granules. These ones, dragged by the interstitial fluid, flow along the elastic fibers towards the small blood vessels and the eccrine sweat glande, where they stay entrapped in anional seats in the basement membranes, and cover a surface much larger than the starting fragment.