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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1998 December;133(6):465-8
Effect of cefuroxime axetil in the treatment of papular-postular acne
Rocco D. 1, Pagnini U. 2, Rocco A. 1
1 Ospedale Ascalesi - Napoli, Ambulatorio di Dermatologia, Università degli Studi Federico II - Napoli;
2 Dipartimento di Patologia e Sanità Animale
Background. This study was designed to evalue the clinical and bacteriological efficacy of cefuroximeaxetil versus minocycline treatment in therapy of patients with papular-pustular acne.
Methods. A total of 64 patients, 34 males and 30 females, aged from 12 to 26 years were enrolled in this study. Patients were divided into three groups. Group 1 was treated with cefuroximeaxetil, group 2 with placebo and group 3 with minocycline. During the examination, material was obtained for bacterial culture from the skin lesions of all patients by either needle aspiration or sterile swab. Swab specimens were obtained directly from the daining lesions in order to minimize contamination with uninvolved skin flora. Thirty-five strains of P. acne, 27 strains of St. epidermidis and 12 strains of St. aureus were isolated. All isolated were identified by standard microbiological methods. Sensitivities to cefuroximeaxetil were determined by the Kirby-Bauer method. The evaluation of P. acne was carried out according to the method of Williamson and Kligman.
Results. The data obtained proved a remarkable decrease of skin lesions with resolution of clinical symptoms and eradication of the initial pathogens from subsequents cultures with both antibiotics.
Conclusions. Because of the lack of side effects during long term therapy, the cefuroximeaxetil could be considered a quite safe and efficacious therapy in the treatment of acne.