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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1998 December;133(6):411-5
Phototherapy of HIV-associated eosinophilic folliculitis. Preliminary results
Gnecchi L., Caccialanza M., Piccinno R., Beretta M. V.
Department of Photoradiotherapy, Institute of Dermatological Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan
Background. Eosinophilic folliculitis human immunodeficiency virus associated (EF-HIV), actually considered as a well defined clinical entity, is a skin disease whose therapeutic approach is still controversial. Up to now many therapies have been employed with non univocal results. The purpose was to test phototherapy effectiveness, in a correctly classified and studied group of patients with EF-HIV.
Materials and methods. A retrospective study was performed in five male patients who underwent phototherapy in the period 1994-1997. During the treatment none of the patients was taking any medications for pruritus. The ultraviolet light sources employed had an emission spectrum in both the UVB and UVA range. Two or three sessions were performed weekly. The total doses of ultraviolet radiaton administered ranged from 8.6 to 338 J/cm2 (mean total dose: 89.13 J/cm2).
Results. In 3 cases therapy effectiveness was evaluated as marked (>70% in decreasing pruritus and in disappearing skin lesions); in 1 case as mild (<50 with respect to the same parameters ) and in the remaining case as none. Both pruritus and skin lesions were relieved after a mean of 8 sessions (range 6-12). It was possible to follow the evolution of EF-HIV for a period of 1-18 month (mean 5.4 month) from the end of phototherapy. The therapy was free from side effects.
Conclusions. Our results, that we consider as preliminary because they refer to a few cases and with a short follow-up, show a favorable efficacy of phototherapy in relieving pruritus and in decreasing skin lesions. Nevertheless, clinical manifestations sometimes recur after stopping phototherapy. This treatment is also important in terms of safety, the lack of side effects and because it can be repeated over time.