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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 1998 December;133(6):411-5

language: English

Phototherapy of HIV-asso­ciat­ed eosin­o­phil­ic fol­lic­u­litis. Preliminary ­results

Gnecchi L., Caccialanza M., Piccinno R., Beretta M. V.

Department of Photoradiotherapy, Institute of Dermatological Sciences, University of Milan, Ospedale Maggiore ­IRCCS, Milan


Background. Eosinophilic fol­lic­u­litis ­human immu­no­def­i­cien­cy ­virus asso­ciat­ed (EF-HIV), actu­al­ly con­sid­ered as a ­well ­defined clin­i­cal ­entity, is a ­skin dis­ease ­whose ther­a­peu­tic ­approach is ­still con­tro­ver­sial. Up to now ­many ther­a­pies ­have ­been ­employed ­with non uni­vo­cal ­results. The pur­pose was to ­test pho­to­ther­a­py effec­tive­ness, in a cor­rect­ly clas­si­fied and stud­ied ­group of ­patients ­with EF-HIV.
Materials and meth­ods. A ret­ro­spec­tive ­study was per­formed in ­five ­male ­patients who under­went pho­to­ther­a­py in the peri­od 1994-1997. During the treat­ment ­none of the ­patients was tak­ing any med­i­ca­tions for prur­it­us. The ultra­vi­o­let ­light sourc­es ­employed had an emis­sion spec­trum in ­both the UVB and UVA ­range. Two or ­three ses­sions ­were per­formed week­ly. The ­total dos­es of ultra­vi­o­let radi­a­ton admin­is­tered ­ranged ­from 8.6 to 338 J/cm2 (­mean ­total ­dose: 89.13 J/cm2).
Results. In 3 cas­es ther­a­py effec­tive­ness was eval­u­at­ed as ­marked (>70% in decreas­ing prur­it­us and in dis­ap­pear­ing ­skin ­lesions); in 1 ­case as ­mild (<50 ­with ­respect to the ­same param­e­ters ) and in the remain­ing ­case as ­none. Both prur­it­us and ­skin ­lesions ­were ­relieved ­after a ­mean of 8 ses­sions (range 6-12). It was pos­sible to fol­low the evo­lu­tion of EF-HIV for a peri­od of 1-18 ­month (­mean 5.4 ­month) ­from the end of pho­to­ther­a­py. The ther­a­py was ­free ­from ­side ­effects.
Conclusions. Our ­results, ­that we con­sid­er as pre­lim­i­nary ­because ­they ­refer to a few cas­es and ­with a ­short fol­low-up, ­show a favor­able effi­ca­cy of pho­to­ther­a­py in reliev­ing prur­it­us and in decreas­ing ­skin ­lesions. Nevertheless, clin­i­cal man­i­fes­ta­tions some­times ­recur ­after stop­ping pho­to­ther­a­py. This treat­ment is ­also impor­tant in ­terms of safe­ty, the ­lack of ­side ­effects and ­because it can be repeat­ed ­over ­time.

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