Advanced Search

Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 1998 June;133(3) > Giornale Italiano di Dermatologia e Venereologia 1998 June;133(3):163-70

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEGIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820

 

Giornale Italiano di Dermatologia e Venereologia 1998 June;133(3):163-70

    ORIGINAL ARTICLES

Skin diseases in children with HIV infection

Patrizi A. 1, Neri I. 1, Trestini D. 1, Ricci G. 2, Masi M. 2

1 Università degli Studi - Bologna, Dipartimento di Medicina Clinica Specialistica e Sperimentale;
2 Unità complessa di Scienze Pediatriche, Mediche Chirurgiche, III Clinica Pediatrica

Background. The acquired immunodeficiency syndrome (AIDS) in children is now to be considered a clinical entity separate and distinct from AIDS in adults. The majority of children become infected by trasmission of the virus from an infected mother. Several dermatological manifestations have been associated with the syndrome in children including candidiasis, dermatophyte infection, molluscum contagiosum, herpes simplex and zoster, bacterial infections, malignant neoplasias and hyperproliferative epidermal disorders. In general, cutaneous infections tend to be more severe and less responsive to conventional treatment than in healthy children.
Objective. Personal experience regarding muco-cutaneous manifestations of human immunodeficiency virus infection and acquired immunodeficiency syndrome in children is presented.
Methods. Fourteen children vertically infected with HIV, were evaluated for CD4+cell count, CD4+/CD8+ ratio and presence of muco cutaneous diseases.
Results. The severity of dermatologic manifestations appeared to be related to the immune status of the patients. More severe CD4+ cell depletion was associated with a wider spectrum and increased severity of dermatologic manifestations.
Conclusions. This study confirms the large spectrum of cutaneous manifestations in children with HIV infection which are similar to those usually reported in the literature. Skin diseases may represent one of the first signs of the HIV infection and may also serve to alert the physician to a deterioration of the immunocompetence of the patient. In fact, the more severe cutaneous manifestations which are also less responsive to treatment appear when the number of CD4+lymphocytes is under 200 cells/ mmc.

language: Italian


FULL TEXT  REPRINTS

top of page