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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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CASE REPORT  


Giornale Italiano di Dermatologia e Venereologia 1998 April;133(2):135-9

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: Italian

Angiosarcoma of the face. Case report

Lisato L. 1, Pagani W. 2, Chiacchiarini A. 2

1 Presidio Ospedaliero - Rovigo, Servizio di Anatomia Patologica (Primario: Dott. G. Barucchello);
2 Divisione di Dermatologia (Primario: Dott. G. Lorenzi)


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Cutaneous angiosarcoma is a rare neoplasm which almost exclusively occurs in three different clinical settings: in areas of chronic lymphedema of the limbs, in the site of previous radiation therapy, on the face and scalp of elderly patients. Early diagnosis is important because of high frequency of distant metastases and of local recurrences, due to multifocality and infiltrative spreading in superficial and deep tissues. A cutaneous angiosarcoma arising on the right temporal region in a 85-year-old woman is described. Clinically, the lesion appeared as a rapidly-growing erythematous nodule. Histologic examination showed a prevalent epithelioid pattern with some spindle-cell and angiomatoid areas. Immunohistochemical stains demonstrated positivity for the endothelial markers factor VIII-Related Antigen and CD31, and negativity for cytokeratins. The clinical behaviour was aggressive, with local recurrence after a few months, in spite of the wide margin of normal tissue; subsequently, a further large surgical excision with parotidectomy and submandibular lymphadenectomy was performed.

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