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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 1998 April;133(2):105-7
Porphyria cutanea tarda and hepatitis C infection. A frequent association
Bettoli V., Bertelli G., Lombardi A., Pazzaglia M.
Università degli Studi - Ferrara, Istituto di Clinica Dermatologica
Background. Porphyria cutanea tarda is an etiologically heterogeneus syndrome, it is due to either a sporadic or genetically transmitted defect of the uroporphyrinogen decarboxylase enzyme (URO-DEC, EC 18.104.22.168). Previous reports have indicated a high prevalence of hepatitis C virus infection in patients with sporadic porphyria cutanea tarda (PCT) in Europe and in the USA.
Methods. The purpose of this investigation was to evaluate the prevalence and incidence of hepatitis C virus infection in 7 patients suffering from sporadic porphyria cutanea tarda.
Results. The incidence found was 85.7%.
Conclusions. According to other European reports, these data suggest that the hepatitis C virus could be an important triggering factor for porphyria cutanea tarda.