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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Riccio G., Procaccini E. M., Schettino A., Monfrecola G.
Università degli Studi di Napoli «Federico II» - Napoli, Clinica Dermatologica
Background. It has already been demonstrated that UV light is able to induce antigenic changes in Langerhans cells (LC) and the skin LC depletion after single or serial exposures.
In a previous study we have shown in human volunteers that visible light (VIS) cause a 70% depletion of human epidermal LC defined by monoclonal antibody (LEU 6) after a VIS dose corresponding to a solar exposure of 2 hours during the summer at our latitude.
Besides, we have shown in mice that VIS causes a membrane markers depletion at doses higher than 100 J/cm2 and a complete depletion at a dose of 700 J/cm2. The electron microscopic analysis showed a destruction of these cells.
Materials and methods. In this study, the time course of the epidermis recolonization after a VIS irradiation of 700 J/cm2 inducing the complete depletion of the epidermis LC, has been analyzed.
Balb/c mice were exposed after depilation to the VIS irradiation and the biopsy punch were done each day for 8 days.
Results and conclusions. Results show that epidermis LC become to be detectable 48 hours after VIS irradiation and a complete recolonization occurs after 7 days.