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A Journal on Surgery

Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index

Frequency: Bi-Monthly

ISSN 0394-9508

Online ISSN 1827-1782


Chirurgia 2016 April;29(2):34-45


Epidemiology, diagnosis and treatment of chronic venous disease: a systematic review

Raffaele SERRA 1, 2, Raffaele GRANDE 2, Lucia BUTRICO 2, Francesco FUGETTO 3, Stefano DE FRANCISCIS 1, 2

1 Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2 Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy; 3 School of Medicine, University of Modena and Reggio Emilia, Modena, Italy

INTRODUCTION: The spectrum of Chronic venous disease (CVD) ranges from varicose veins to leg edema, and serious dermal clinical manifestations consisting of hyperpigmentation, eczema, lipodermatosclerosis, and venous skin ulceration. CVD management has undergone a revolution based on technological advances: duplex ultrasound has impacted almost every facet of phlebology, including preoperative diagnosis, periprocedural monitoring, postoperative surveillance, and even our understanding of the disease process itself. Furthermore, numerous successful treatment options, based on surgical, compression and medical therapy, are available for patients with CVD. This study performs a systematic and comprehensive analysis of the most recent scientific literature on the epidemiology of CVD, diagnostic procedures and conventional and innovative treatments.
EVIDENCE ACQUISTION: PubMed and ScienceDirect databases were searched for articles using the terms: Chronic Venous Disease, Medical and Surgical management, chronic inflammation and MMPs.
EVIDENCE SYNTHESIS: The prevalence of CVD among individuals younger than 30 years is <10% for men and for women; the prevalence in men and women aged ≥70 years is 57% and 77 respectively.
CONCLUSIONS: A multidisciplinary comprehensive approach to CVD improves outcomes through dedicated nurses, physician assistants, physical therapists, medical physicians and surgeons.

language: English


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