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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2014 February;27(1):21-4
Colorectal cancer treatment in HIV positive patients
Fisichella R., Spartà D., Di Dio L., Puglisi L., D’Agata A., Fiorica F., Berretta S.
Dipartimento di Chirurgia dell’Università di Catania, P.O. Policlinico, U.O.C. di Clinica Chirurgica II, Catania, Italia
The authors investigate about the treatment of colorectal cancer in HIV-positive patients. Recent studies have shown a 3 fold increased risk of developing non-AIDS cancers in HIV-infected patients when compared to the general population. Current studies suggest that HIV-positive patients with colorectal cancer, particularly with normal CD4 count, should be treated with the same approache to their HIV-negative patient. The risks of postoperative complications (infection, wound dehiscence) result higher in HIV-positive rather than in HIV-negative and these patients tend to have less favourable prognosis and there is an increased frequency of chemotherapy-related toxicities when HAART was coadministered with antineoplastic drugs.