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Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1782
Zheng Y.-C. 1, Jung S.-M. 2, Chang J. W.-C. 3, Huang Y.-C. 3
1 Department of Pathology Chang Gung Memorial Hospital at Linkou Chang Gung University, Taiwan, Republic of China;
2 Department of Hematology/Oncology Chang Gung Memorial Hospital at Linkou Chang Gung University, Taiwan, Republic of China;
3 Department of Neurosurgery Chang Gung Memorial Hospital at Linkou Chang Gung University, Taiwan, Republic of China
The incidence of melanoma is less frequent in Asians. Leptomeningeal melanocytomas are sometimes reported, but are mostly in the brains. Primary intramedullary melanomas are extremely rare and only presented in a few case reports. Herein we presented a case with intramedullary melanoma with a long-term follow-up. A 59-year-old female presented with bilateral legs weakness and was diagnosed with an intramedullary lesion extending from T11-12. She received an open biopsy procedure in 1995. She was neurologically stable post-operatively and received another open biopsy procedure in 1997 due to uncertain pathologic diagnosis. The second pathology revealed a hypercellular, melanin-deposited lesion, and strongly expression of melanoma-associated proteins. The patient subsequently received chemotherapy, immunotherapy and regular followed at our clinics for over 14 years without progression. Primary intramedullary melanoma may differ clinically from metastatic melanoma with a more favorable outcome, compatible with most previous reports.