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A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2012 October;25(5):349-50
Castleman’s disease of parotid: a rare location. A case report
Portale T. R., Branca A., Pesce A., Scilletta R., Puleo S.
University of Catania, Catania, Italy
Castleman’s disease of the parotid is a very rare disorder characterized by non-neoplastic growths in lymphnodes in any body regions, although over 60% of cases are located in the mediastinum. The head and neck is the second most commonly involved site, with up to 14% of cases. Of these, nearly 85% are located in the neck. These lesions rarely occur in the salivary glands. Unicentric and multicentric Castleman’s disease are being distinguished, the latter harboring an unfavorable prognosis. The etiology is uncertain. We present a case of unicentric Castleman’s disease in a 51-year-old woman without associated neoplastic, autoimmune or infectious diseases. The lesion was located in the right parotid gland mimicking benign neoplasia and surgically resected. The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis, onion-skinning and rich interfollicular vascularization. The diagnosis of mixed cellularity type Castleman’s disease was established and the patient recovered well.