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Chirurgia 2012 April;25(2):105-9

language: English

Drug-induced gingival overgrowth: a clinical and histopathological report

Santana Coimbra L. 1, De Andrade C. R. 1, Schneider Herrera B. 1, Cirelli J. A. 2, Spolidorio L. C. 1

1 Department of Physiology and Pathology, School of Dentistry at Araraquara, University Estadual Paulista, UNESP, Araraquara, São Paulo, Brazil;
2 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, University Estadual Paulista, UNESP, Araraquara, São Paulo, Brazil


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Gingival overgrowth is a significant problem faced by periodontists and is particularly associated with the use of certain drugs such as nifedipine, a high-specificity calcium channel blocker used for the treatment and prophylaxis of certain cardiovascular diseases. Development of gingival overgrowth is characterized by increased collagen in gingival tissue. In general is asymptomatic, at times associated with spontaneous bleeding and ulceration and can promote aesthetic changes and compromise hygiene habits and mastication of the patient. The severity of the symptoms is associated with the presence of risk factors such association with other drugs. This paper aims to present a case report of a patient with generalized gingival overgrowth, with more severe characteristics in the anterior mandible induced by chronic use of nifedipine who underwent basic non-surgical periodontal treatment including supra and sub-gingival scaling and root planning in both jaws associated with rigorous oral hygiene instructions and surgical therapy in the anterior mandible, the most affected area, to remove the excess of gingival tissue. Nifedipine was replaced by the patient cardiologist to propanolol hydrochloride (40 mg/kg) in an attempt to minimize unwanted side effects. After 6 month follow-up, no recurrence was observed, oral hygiene had improved and the patient had clinical periodontal health and esthetic satisfaction.

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