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A Journal on Surgery

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Chirurgia 2011 October;24(5):297-300

language: English

Extracerebellar liponeurocytoma: report of two cases

Horkayne-Szakaly I. 1, Sekula R. F. 2, Smith A. 3, 4, Smirniotopoulos J. D. 3, 4, Rushing E. J. 1

1 Departments of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
2 Department of Neurosurgery, Allegheny Neuroscience Institute, Pittsburgh, PA, USA
3 Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
4 Department of Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, USA


Liponeurocytoma (LN) is a rare tumor with a favorable prognosis, characteristically located in the cerebellum of middle-aged adults. Other locations are highly unexpected, with only four previous cases reported in the English literature. We present two more examples of this rare tumor and clinical findings, pathology, imaging, differential diagnosis. The first patient is a 75-year-old man (the oldest to date) who presented with a 3-month history of progressive headache and mental status changes, and the second, in a 23-year-old man with an 8-month history of headache and papilledema.Endoscopic-assisted biopsy and subtotal resection of the mass was performed in Case 1, and in the second case, right frontal craniotomy was performed for gross total resection of the lesion. These cases illustrate that LN should be considered in the differential diagnosis of mass lesions in the lateral ventricles. Complete resection should be attempted to reduce the likelihood of recurrence and ensure an optimal outcome.

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