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A Journal on Surgery

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Chirurgia 2011 October;24(5):291-2

language: English

Pure stage I seminoma with an extremely elevated beta human chorion gonadotropin (β-hCG) of 3843 IU/L in a 31-year-old man treated by orchiectomy and adjuvant radiotherapy

Kalaitzis C., Bantis A., Giannakopoulos S.

Department of Urology, University of Thrace, Alexandroupolis, Greece


High levels of beta human chorion gonadotropin in patients with pure seminoma of the testis are very rare. In such cases it is the question, whether these tumours can be effectively treated adjuvant such as pure seminomas or whether they must be considered as non-seminomatous tumours and whether extreme elevated beta human chorion gonadotropin has any influence on disease progression and patient prognosis. We present a case of a 31-year-old man with a histologically pure seminoma, stage I, and a serum beta human chorion gonadotropin of 3843 IU/L at time of diagnosis. To our knowledge this is one of the highest value of beta human chorion gonadotropin ever reported with a stage I pure seminoma. Patient underwent orchiectomy and adjuvant radiotherapy of paraaortal lymph nodes with a total dose of 26 Gy. His beta human chorion gonadotropin was undetectable by postoperative day 14. The two-year follow-up showed disease free status. Pure seminomas with extremely elevated serum beta human chorion gonadotropin can be managed as classic seminomas. Management is stage dependent. Elevated serum appears to have no a predictive value, at least in stage I pure seminomas.

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