Total amount: € 0,00
HOW TO ORDER
A Journal on Surgery
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2011 October;24(5):251-5
Positive pleural lavage cytology results highly related to local recurrence: institutional report and pooled analysis findings
Araki O., Chida M., Karube Y., Hayama M., Tamura M., Kobayashi S., Ishihama H., Oyaizu T.
Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan
Aim. A positive result of a pleural lavage cytology (PLC) examination is an independent predictor of poor survival in patients undergoing lung resection for non-small-cell lung cancer.
Methods. We analyzed our institutional data regarding PLC results obtained during surgery and also pooled those with findings of other published studies to analyze the impact of positive results on recurrence.
Results. There were 20 PLC-positive (6.4%) and 291 PLC-negative (93.6%) patients studied from our institution. Seventy-six in the PLC-negative group (26%) and 20 in the PLC-positive group (60%) had recurrence. The survival rate for the PLC-negative group was significantly superior (p=0.039). Next, pooled analyses of data for 252 PLC-positive and 3166 PLC-negative patients were performed, which showed that positive patients had a 10-fold greater relative risk of recurrence of pleural recurrence (p<0.0001). Positive patients also had 2-fold greater risks of both loco-regional recurrence and distant metastasis.
Conclusion. PLC-positive patients have a significantly higher risk of pleural recurrence. Additional studies are necessary to determine whether pleural recurrence is correlated to outcome.