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Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1782
Küçükkartallar T., Sahin M., Çakir M., Kafali E., Saygun O., Tekin A., Ünlü Y., Aktürk S.
Deparment of General Surgery, Meram Medical Faculty, Selcuk University, Konya, Turkey
AIM: The aim of this study is to compare the severity of tissue reaction in anterior abdominal wall caused by synthetic meshes in different fiber thickness.
METHODS:In all rats, abdominal wall along the midline, skin and subcutaneous tissue was incised 2 cm along and a 3x3 cm2 area was dissected. Group I: Only dissection was applied. Group II: A 2x2 cm2 diameter mesh with 320 micron mesh thickness was placed on the dissected area. Group III: A 2x2 cm2 diameter mesh with 600 micron mesh thickness was placed on the dissected area.
RESULTS: Infection and seroma frequency in incision line was defined as, In Group I (15 %) in three rats, in Group II (25 %) in 5 rats and in Group III (35 %) in 7 rats. Measured plasma IgE levels in rats were found meaningfully high compared to that of control group (p<0.05). The value of thin mesh group was found meaningfully low compared to that of thick mesh group (p<0.05). A meaningful difference was not observed among the leucocytes values of the groups (p<0.05). The fibrosis measurements in group III was higher than that of the other group (p<0.05).
CONCLUSION: Reaction has occurred for both meshes. It has been observed that the reaction occurred in thin mesh group was meaningfully lower compared to the thick mesh group as a result of serological tests, electron and light microscopic examinations. Referencing this, it has been understood that the reaction occurred has shown parallelism with the mass of mesh.